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KMID : 0363320120330040511
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Journal of Korean Oriental Internal Medicine
2012 Volume.33 No. 4 p.511 ~ p.519
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The Effects of SBD-1 on Hangover Syndrome : a Randomized Double-blind Crossover Preliminary Study
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Jeong Hyun-Suk
Kang Sei-Young
Han Hyun-Jin
Jang In-Soo
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Abstract
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Objectives : This study investigated the effect of Sinseonbulchuidan (SBD-1) on hangover syndrome. We undertook this study to test whether SBD-1 is effective in preventing the signs and symptoms of alcohol-induced hangover.
Methods : Fifteen healthy volunteers participated in this double-blind randomized crossover study. All participants received either SBD-1 or indistinguishable placebo capsules before alcohol consumption. The primary outcome measure was the difference in hangover severity scores between SBD-1 and placebo intervention. Secondary outcome measure was the difference in profile of mood states (POMS) between SBD-1 and placebo intervention.
Results : After alcohol exposure, the overall symptom scores were significantly decreased in the SBD-1 group compared with those given a placebo. The mean scores for the hangover symptoms were high in the placebo group, and statistical significance was observed in 4 symptom scores (loss of appetite, stomachache, nausea, and total score). There were no differences in the POMS and cognitive performance test results between SBD-1 and placebo intervention.
Conclusions : We conclude that the SBD-1 is effective in preventing the signs and symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.
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KEYWORD
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Sinseonbulchuidan, alcohol hangover, Korean medicine, acute hangover scale
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